When compared with control mice, thoracic aortic rings from adult male MSEW mice displayed significant endothelial dysfunction that was reversed by the superoxide scavenger, polyethylene glycol-superoxide dismutase (PEG-SOD). Control litters remained undisturbed until weaning at PD21. Studies employed a mouse model of ELS, maternal separation with early weaning (MSEW), in which litters were separated from the dam for 4 h/day and 8 h/day (PD6-16), and weaned at PD17. ![]() Because oxidative stress and endothelial dysfunction are major contributors to cardiovascular risk, we hypothesized that ELS induces endothelial dysfunction in adult male mice via increased superoxide production. Early life stress (ELS) is a risk for cardiovascular disease in adulthood although very little mechanistic insight is available.
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